Category Archives: Uncategorized

Benefits of The Entourage Effect – Full Spectrum CBD

The Entourage Effect: Chemical Teamwork

Raphael Mechoulam

First described in 1998 by Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam, the basic idea of the entourage effect is that cannabinoids within the cannabis plant work together, or possess synergy, and affect the body in a mechanism similar to the body’s own endocannabinoid system.

This theory serves as the foundation for a relatively controversial idea within pharmacology community, that in certain cases whole plant extractions serve as better therapeutic agents than individual cannabinoid extractions. The entourage effect theory has been expanded in recent times by Wagner and Ulrich-Merzenich, who define the four basic mechanisms of whole plant extract synergy as follows:

  1. Ability to affect multiple targets within the body
  2. Ability to improve the absorption of active ingredients
  3. Ability to overcome bacterial defense mechanisms
  4. Ability to minimize adverse side effects.

Affecting Multiple Targets

Many studies have demonstrated the effectiveness of cannabis as a therapeutic agent for muscle spasms associated with multiple sclerosis. A study conducted by Wilkinson and colleagues determined that whole-plant extracts were more effective than THC alone.

Researchers compared 1mg THC vs. 5mg/kg cannabis extract with the equivalent amount of THC, and found the whole plant extract to have significantly more antispastic effect.

The researchers attributed this result to the presence of cannabidiol (CBD) within the cannabis extract, which helps to facilitate the activity of the body’s endocannbinoid system.

Improving Absorption Of Active Ingredients

The entourage effect can also work to improve the absorption of cannabis extracts. Cannabinoids are chemically polar compounds, which at times makes them difficult for the body to absorb in isolation.

“With the assistance of terpenoids like caryophyllene, absorption of cannabinoids can be increased.”

Absorption of topicals provides a prototypical example of this problem. The skin is made up of two layers, also known as a bi-layer, which makes it difficult for very polar molecules like water and cannabioids to pass through.

With the assistance of terpenoids like caryophyllene, absorption of cannabinoids can be increased and therapeutic benefits achieved.

Overcoming Bacterial Defense Mechanisms

The entourage effect also accounts for cannabis extracts to be effective in treating various bacterial infections. There are a number of studies which show the antibacterial properties of cannabinoids.

“Whole-plant cannabis extracts have non-cannabinoid constituents which also have antibacterial properties.”

However, bacteria develop defense mechanisms over time to combat the effects of antibiotics ultimately allowing them to become resistant to therapies which were previously effective.

Thus, it is beneficial that whole-plant cannabis extracts have non-cannabinoid constituents that also have antibacterial properties. These molecules attack bacteria through pathways which differ from cannabinoid pathways. Given the attack on multiple fronts, the development of bacterial resistance is limited.

Minimizing Adverse Side Effects

Finally, the entourage effect allows certain cannabinoids to modulate the negative side effects of other cannabinoids. The most fitting example of this is CBD’s ability to modulate the perceived negative effects of THC.

Many patients have heard about (or experienced) the increased anxiety and paranoia sometimes associated with cannabis consumption. Thanks to the entourage effect, research has shown that CBD can be effective in minimizing the anxiety associated with THC, lowering users’ feelings of paranoia.

As you can see, THC, CBD, and the remaining cannabinoids don’t have to compete with one another – they can work in tandem alongside the other components of cannabis extracts to provide therapeutic relief for a wide variety of ailments.

Bennistar CBD produces Full Spectrum CBD tinctures with noticeably higher percentages of Other Minor Cannabinoids such as CBG and CBC at: Launch

Bennistar CBD is please to announce the launch of our website Bennistar formulates the highest possible quality CBD Oil tinctures for people and for pets. To celebrate all of our Full Spectrum CBD tinctures are on sale until 1/20/20.

Full Spectrum CBD is our preferred formulation because it includes CBD and also other cannabinoids, terpenes, and a very low dose of THC (<.3%). This combination promotes what is called the “Entourage Effect”, which provides additional benefits beyond only CBD.

Bennistar CBD Oil Product Launch

Bennistar CBD is pleased to announce the completion of our hemp harvest by our sister company Peak Health Holdings, LLC. Peak Health Holdings finished our harvest with a very high CBD content in our hemp. Bennistar CBD is pleased to announce the launch of our Bennistar CBD Oil line of products. Our customers can be assured of only the highest quality and most pure forms of CBD tinctures and pet products. Please visit our website at:

What is CBD?

CBD stands for Cannabidiol (Can-a-bid-i-ol). CBD is a main component of cannabis and in a class of molecules called cannabinoids found in the plant genus Cannabis Sativa (both hemp and marijuana).  It is just one of over 100 compounds found in cannabis. CBD is a non-psychoactive component that may hold a wide variety of potential health benefits, and it does not induce the psychoactive or “high” feelings that THC does.

The human body has a system of receptors known as the endocannabinoid system which utilizes cannabinoids in a wide variety of ways in our bodies. CBD is the most used and pure form of cannabidiol extract from the hemp plant.   Our sister company farms hemp using organic practices and extracts our hemp or sources only the most refined CBD extracts.  Bennistar CBD tinctures will never have a dirty, or earthy, or burnt flavor of some tinctures that use less refined or less expensive extracts.